ADCK5

Uncharacterized aarF domain-containing protein kinase 5 · Q3MIX3 · ADCK5 on Sugi Atlas →

889 patent compounds predicted against ADCK5, 814 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Linsitinib (SCHEMBL400369)	1.00	1/20
Linsitinib (SCHEMBL400734)	1.00	1/20
Linsitinib (SCHEMBL400735)	1.00	1/20
Linsitinib (SCHEMBL10255925)	1.00	1/20
Linsitinib (SCHEMBL528637)	0.98	1/20
Linsitinib (SCHEMBL528638)	0.98	1/20
Linsitinib (SCHEMBL1758871)	0.92	1/20
Linsitinib (SCHEMBL1758866)	0.87	1/20
Linsitinib (SCHEMBL1758701)	0.84	1/20
SCHEMBL13447913	0.84	1/20
SCHEMBL13448066	0.82	1/20
SCHEMBL397576	0.81	1/20
SCHEMBL13812511	0.81	1/20
SCHEMBL399357	0.81	1/20
SCHEMBL399670	0.81	1/20
SCHEMBL401531	0.81	1/20
Linsitinib (SCHEMBL1758705)	0.80	1/20
SCHEMBL10225384	0.79	1/20
SCHEMBL13447908	0.79	1/20
SCHEMBL13447930	0.79	1/20

Clinical trials — most relevant to ADCK5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenomic Evaluation of Antihypertensive Responses	PHASE4	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Validation of the RADIAL Algorithm for Diagnosis of Autosomal Recessive Cerebellar Ataxia	nan	RECRUITING
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome	nan	RECRUITING
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing	nan	UNKNOWN
Identification of New FTLD Genes	nan	UNKNOWN
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Study of the Genetic Factors Involved in Autism and Related Disorders	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS	nan	RECRUITING
Recurrent Acute Myocarditis Registry	nan	UNKNOWN
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Genome Environment Microbiome and Metabolome in Autism Study	nan	COMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADCK5 binder may also engage these)

Protein	Name	Similarity
Q80V03	—	1.000	Q80V03 →
Q6AY19	—	0.983	Q6AY19 →
Q8Y275	—	0.978	Q8Y275 →
A0A172M468	—	0.978	A0A172M468 →
Q9W133	—	0.977	Q9W133 →
Q5BJQ0	—	0.977	Q5BJQ0 →
A0A179HKZ8	—	0.977	A0A179HKZ8 →
B2SX38	—	0.976	B2SX38 →
Q566J8	—	0.976	Q566J8 →
Q3BZ34	—	0.976	Q3BZ34 →
Q06567	—	0.975	Q06567 →
Q87UZ0	—	0.975	Q87UZ0 →
Q8PQT0	—	0.975	Q8PQT0 →
C3K8U2	—	0.975	C3K8U2 →
B2ST34	—	0.975	B2ST34 →
Q48PJ6	—	0.975	Q48PJ6 →
B0U2R2	—	0.974	B0U2R2 →
COQ8B	Atypical kinase COQ8B, mitochondrial	0.974	landscape →
Q8K370	—	0.974	Q8K370 →
Q3U3Q1	—	0.974	Q3U3Q1 →
Q9PCE8	—	0.974	Q9PCE8 →
Q145N7	—	0.974	Q145N7 →
A2Z1F5	—	0.974	A2Z1F5 →
B9ME24	—	0.974	B9ME24 →
A3QJU3	—	0.974	A3QJU3 →
A1JIF4	—	0.974	A1JIF4 →
A9BP42	—	0.973	A9BP42 →
Q1CNB2	—	0.973	Q1CNB2 →
Q8ZAM1	—	0.973	Q8ZAM1 →
Q66FS8	—	0.973	Q66FS8 →