Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30211424 | 1.00 | POLB (0.34) | POLBCASP6BRD4PKMPDK2 | |
| SCHEMBL30740563 | 0.79 | CYP1A2 (0.51) | BRD4PDK2 | |
| SCHEMBL24898554 | 0.79 | CYP1A2 (0.51) | BRD4PDK2 | |
| SCHEMBL24898318 | 0.76 | PKM (0.35) | PKM | |
| SCHEMBL2012314 | 0.74 | PDK2 (0.49) | PKMPDK2 | |
| SCHEMBL24897752 | 0.72 | IDO1 (0.36) | POLBCASP6IDO1PGR | |
| SCHEMBL7825677 | 0.71 | PGR (0.50) | PDK2PGR | |
| SCHEMBL2265792 | 0.69 | PGR (0.37) | POLBCASP6PDK2PGR | |
| SCHEMBL29860253 | 0.69 | PGR (0.44) | PGR | |
| SCHEMBL17950681 | 0.66 | KMT2A (0.66) | POLBPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288242-A1 | PI3Kα INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |