Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.63 |
| ▸ | RORB | Q92753 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 5/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.52 |
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492109 | 0.88 | TRPM8 (0.65) | ALDH1A1HSD17B10TRPM8DHODHPDE4A | |
| SCHEMBL1968418 | 0.88 | TRPM8 (0.65) | ALDH1A1HSD17B10TRPM8DHODHPDE4A | |
| SCHEMBL11164259 | 0.88 | ALDH1A1 (0.77) | ALDH1A1HSD17B10DHODHKDM4EMAPT | |
| SCHEMBL1920374 | 0.87 | TRPM8 (0.64) | ALDH1A1HSD17B10TRPM8DHODHPDE4A | |
| SCHEMBL24508984 | 0.86 | ALDH1A1 (0.73) | ALDH1A1HSD17B10TRPM8DHODHKDM4E | |
| SCHEMBL18342059 | 0.86 | ALDH1A1 (0.73) | ALDH1A1HSD17B10TRPM8RORBDHODH | |
| SCHEMBL11161509 | 0.85 | ALDH1A1 (0.76) | ALDH1A1HSD17B10TRPM8DHODHKDM4E | |
| SCHEMBL330552 | 0.85 | ALDH1A1 (1.00) | ALDH1A1HSD17B10TRPM8DHODHKDM4E | |
| SCHEMBL18342124 | 0.84 | ALDH1A1 (0.70) | ALDH1A1HSD17B10TRPM8DHODHKDM4E | |
| SCHEMBL11165291 | 0.83 | ALDH1A1 (0.69) | ALDH1A1HSD17B10RORBDHODHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379543-A2 | THIAZOLYL-BENZIMIDAZOLES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| US-8044213-B2 | Thiazolyl-benzimidazoles | HOFFMANN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| WO-2010121675-A2 | THIAZOLYL-BENZIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CAI JIANPING | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160308-A1 | Thiazolyl-Benzimidazoles | CYP3A7, CYP2C19, CYP3A5 | ALDH1A1 100/4885HSD17B10 683/4885TRPM8 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.