Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Limaprost. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 known ✓ | P43116 | 3/20 | 0.73 |
| ▸ | PTGER1 known ✓ | P34995 | 1/20 | 0.62 |
| ▸ | PTGIR | P43119 | 8/20 | 0.73 |
| ▸ | TSHR | P16473 | 3/20 | 0.73 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.73 |
| ▸ | RARB | P10826 | 1/20 | 0.73 |
| ▸ | RARG | P13631 | 1/20 | 0.73 |
| ▸ | DRD1 | P21728 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960063 | 0.94 | PTGIR (0.65) | PTGIRTSHRPTGER4PTGER2HPGD | |
| SCHEMBL960062 | 0.94 | PTGIR (0.65) | PTGIRTSHRPTGER4PTGER2HPGD | |
| SCHEMBL960065 | 0.94 | PTGIR (0.65) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL960148 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL960149 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL23352904 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL373011 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL20815450 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL30532999 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD | |
| Limaprost SCHEMBL30533051 | 0.93 | PTGIR (0.59) | PTGIRTSHRPTGER4PTGER2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380881-B1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2017-01-25 | — | — | EP | disclosed |
| US-20130303535-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | Sumitomo Pharma Co., Ltd. (JP) | 2013-11-14 | — | — | US | disclosed |
| US-8471038-B2 | Bicyclic heterocyclic compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-06-25 | — | — | US | disclosed |
| US-20110294804-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-12-01 | — | — | US | disclosed |
| EP-2380881-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-20090131412-A1 | NOVEL 2-QUINOLONE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
| EP-1908752-A1 | NOVEL 2-QUINOLONE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294804-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | OPRL1, SCN1B, OPRD1 | PTGER2 2748/4885PTGER1 1312/4885PTGIR 1951/4885 |
| US-20090131412-A1 | NOVEL 2-QUINOLONE DERIVATIVE | SCN1B, OPRL1, SCN1A | PTGER2 882/4885PTGER1 514/4885PTGIR 1600/4885 |
| US-20130303535-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | OPRL1, SCN1B, OPRD1 | PTGER2 2748/4885PTGER1 1312/4885PTGIR 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.