Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.49 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3066737 | 0.83 | LIPG (0.41) | LIPGENPP2ALDH1A1LIPE | |
| SCHEMBL10350653 | 0.80 | PTGS2 (0.55) | PTGS2ALDH1A1PDE5ASOAT1HTR7 | |
| SCHEMBL30548746 | 0.80 | PTGS2 (0.55) | PTGS2ALDH1A1PDE5ASOAT1HTR7 | |
| SCHEMBL10504004 | 0.75 | PTGS2 (0.51) | PTGS2ALDH1A1PDE5ASOAT1MTNR1A | |
| SCHEMBL134254 | 0.74 | POLB (0.55) | LIPGALDH1A1LIPE | |
| SCHEMBL29952130 | 0.74 | POLB (0.55) | LIPGALDH1A1LIPE | |
| SCHEMBL3628525 | 0.72 | MEN1 (0.54) | PTGS2ALDH1A1PDE5ASOAT1 | |
| SCHEMBL10144088 | 0.72 | PTGS2 (0.49) | PTGS2ALDH1A1PDE5ASOAT1HTR7 | |
| SCHEMBL26942237 | 0.72 | APOBEC3G (0.57) | PTGS2ALDH1A1PDE5AHTR7 | |
| SCHEMBL29367623 | 0.72 | ENPP2 (0.43) | LIPGENPP2ALDH1A1LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379580-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | Cubist Pharmaceuticals, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010075215-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | CUBIST PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | WO | disclosed |