Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.50 |
| ▸ | TOP1 | P11387 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487138 | 0.89 | CHRM1 (0.52) | CHRM1TOP1TP53 | |
| SCHEMBL2490149 | 0.87 | CHRM1 (0.68) | CHRM1TOP1CDK9 | |
| SCHEMBL2491670 | 0.87 | CHRM1 (0.52) | CHRM1TOP1CDK9TLR7DRD2 | |
| SCHEMBL2489733 | 0.86 | CHRM1 (0.57) | CHRM1TOP1TP53 | |
| SCHEMBL2490524 | 0.83 | CHRM1 (0.71) | CHRM1TOP1TP53 | |
| SCHEMBL2491318 | 0.79 | CHRM1 (0.40) | CHRM1TOP1TP53 | |
| SCHEMBL3239675 | 0.79 | CHRM1 (0.57) | CHRM1TP53 | |
| SCHEMBL2489217 | 0.79 | CHRM1 (0.61) | CHRM1TP53 | |
| SCHEMBL2490230 | 0.77 | CHRM1 (0.68) | CHRM1TOP1 | |
| SCHEMBL2487134 | 0.76 | CHRM1 (0.71) | CHRM1TOP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |