Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PPIA | P62937 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815768 | 0.88 | MEN1 (0.62) | RAB9APOLBPKMNPC1SMN1; SMN2 | |
| SCHEMBL2417590 | 0.87 | NPC1 (0.65) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20080799 | 0.86 | ALDH1A1 (0.54) | RAB9APOLBPKMNPC1SMN1; SMN2 | |
| SCHEMBL18314216 | 0.86 | ALDH1A1 (0.54) | RAB9APOLBPKMNPC1SMN1; SMN2 | |
| SCHEMBL2484277 | 0.85 | MAPT (0.53) | RAB9APOLBPKMNPC1SMN1; SMN2 | |
| SCHEMBL2011651 | 0.83 | RAB9A (0.77) | RAB9APOLBPKMNPC1SMN1; SMN2 | |
| SCHEMBL4958404 | 0.82 | CYP2C19 (0.51) | RAB9APOLBPKMNPC1SMN1; SMN2 | |
| SCHEMBL1805499 | 0.82 | MEN1 (0.67) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1814793 | 0.82 | MEN1 (0.67) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL31171406 | 0.81 | RAB9A (0.63) | RAB9APOLBPKMNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312177-B1 | TRICYCLIC DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | ONCONIC THERAPEUTICS INC (KR) | 2021-04-14 | — | — | EP | disclosed |
| EP-3312177-B1 | TRICYCLIC DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | ONCONIC THERAPEUTICS INC (KR) | 2021-04-14 | — | — | EP | disclosed |
| US-10464919-B2 | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2019-11-05 | — | — | US | disclosed |
| US-20180162834-A1 | Tricyclic Derivative Compound, Method for Preparing Same, and Pharmaceutical Composition Comprising Same | ONCONIC THERAPEUTICS INC. (KR) | 2018-06-14 | — | — | US | disclosed |
| US-20180162834-A1 | Tricyclic Derivative Compound, Method for Preparing Same, and Pharmaceutical Composition Comprising Same | ONCONIC THERAPEUTICS INC. (KR) | 2018-06-14 | — | — | US | disclosed |
| CN-104557691-B | A kind of 3 amine acyl bishydrazide derivatives and its preparation method and application | 中国农业大学 | 2017-10-24 | — | — | CN | disclosed |
| CN-104610140-B | 3-amine acylhydrazone derivative, preparation method and application of 3-amine acylhydrazone derivative | 青岛农业大学 | 2017-01-25 | — | — | CN | disclosed |
| WO-2016200101-A2 | TRICYCLIC DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 제일약품주식회사 | 2016-12-15 | — | — | WO | disclosed |
| CN-104610140-A | 3-amine acylhydrazone derivative, preparation method and application of 3-amine acylhydrazone derivative | UNIV QINGDAO AGRICULTURAL | 2015-05-13 | — | — | CN | disclosed |
| CN-104557691-A | 3-aminoacyl bishydrazide derivatives, and preparation method and application thereof | UNIV CHINA AGRICULTURAL | 2015-04-29 | — | — | CN | disclosed |
| US-8815891-B2 | Tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2014-08-26 | — | — | US | disclosed |
| US-8815891-B2 | Tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2014-08-26 | — | — | US | disclosed |
| EP-2364983-B1 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | JEIL PHARMACEUTICAL CO LTD (KR) | 2013-10-23 | — | — | EP | disclosed |
| EP-2364983-B1 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | JEIL PHARMACEUTICAL CO LTD (KR) | 2013-10-23 | — | — | EP | disclosed |
| CN-102245612-A | Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same | JE IL PHARMACEUTICAL CO LTD | 2011-11-16 | — | — | CN | disclosed |
| EP-2364983-A2 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Jeil Pharmaceutical Co., Ltd. (KR) | 2011-09-14 | — | — | EP | disclosed |
| EP-2364983-A2 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Jeil Pharmaceutical Co., Ltd. (KR) | 2011-09-14 | — | — | EP | disclosed |
| US-20110218193-A1 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2011-09-08 | — | — | US | disclosed |
| US-20110218193-A1 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2011-09-08 | — | — | US | disclosed |
| US-20110218193-A1 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162834-A1 | Tricyclic Derivative Compound, Method for Preparing Same, and Pharmaceutical Composition Comprising Same | TNKS, TNKS2, PARP1 | RAB9A 4372/4885POLB 235/4885PKM 539/4885 |
| US-20110218193-A1 | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | PARP1, PARP15, PARP11 | RAB9A 3767/4885POLB 32/4885PKM 558/4885 |
| US-10464919-B2 | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same | TNKS, TNKS2, PARP1 | RAB9A 4372/4885POLB 235/4885PKM 539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.