Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25198553 | 0.91 | ACHE (0.42) | ACHEMEN1MAPK1KMT2ABPTF | |
| SCHEMBL18007560 | 0.88 | ACHE (0.44) | ACHEMEN1MAPK1KMT2ABPTF | |
| SCHEMBL7581083 | 0.70 | ACHE (0.32) | ACHEMEN1MAPK1KMT2ABPTF | |
| SCHEMBL16843009 | 0.67 | ACHE (0.30) | ACHE | |
| SCHEMBL25198011 | 0.67 | ACHE (0.32) | ACHEMEN1MAPK1KMT2ABPTF | |
| SCHEMBL25213702 | 0.67 | — | — | |
| SCHEMBL337198 | 0.67 | ACHE (0.48) | ACHEMEN1MAPK1KMT2ABPTF | |
| SCHEMBL25196965 | 0.61 | — | — | |
| SCHEMBL25198544 | 0.61 | ACHE (0.42) | ACHEMEN1MAPK1KMT2ABPTF | |
| SCHEMBL15572589 | 0.60 | GAA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12617802-B2 | Sulfonimidamide compounds as NLRP3 modulators | GENENTECH, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-20240336625-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2024-10-10 | — | — | US | disclosed |
| EP-4373826-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2024-05-29 | — | — | EP | disclosed |
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | GENENTECH, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | GENENTECH, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | GENENTECH, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2023004257-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023004257-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2023-01-26 | — | — | WO | disclosed |
| CN-115461120-A | Sulfonylimide compounds as NLRP3 modulators | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159555-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | NLRP3, NLRP1, PYCARD | ACHE 4862/4885MEN1 4442/4885MAPK1 1504/4885 |
| US-12617802-B2 | Sulfonimidamide compounds as NLRP3 modulators | NLRP3, NLRP1, PYCARD | ACHE 4848/4885MEN1 4299/4885MAPK1 1095/4885 |
| US-20240336625-A1 | SULFONIMIDAMDE COMPOUNDS AND USES THEREOF | NLRP3, PYCARD, NLRP1 | ACHE 4171/4885MEN1 2868/4885MAPK1 3652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.