Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.51 |
| ▸ | RXRA | P19793 | 9/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25897473 | 0.86 | BCHE (0.48) | BCHENOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL25820296 | 0.81 | RXRA (0.58) | RXRAGRIN1GRIN2B | |
| SCHEMBL25868678 | 0.81 | RXRA (0.50) | RXRAGRIN1GRIN2BKEAP1NFE2L2 | |
| SCHEMBL10257033 | 0.80 | NOTUM (0.56) | NOTUMRXRAGRIN1GRIN2BKEAP1 | |
| SCHEMBL26326055 | 0.80 | BCHE (0.56) | BCHENOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL24908499 | 0.79 | MIF (0.49) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL13119830 | 0.79 | P2RX7 (0.50) | NOTUMALDH1A1NPC1 | |
| SCHEMBL23603985 | 0.77 | NOTUM (0.59) | NOTUMRXRAGRIN1GRIN2BCA12 | |
| SCHEMBL17452648 | 0.76 | BCHE (0.50) | BCHENOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL23008630 | 0.76 | CYP1B1 (0.37) | NOTUMRXRAGRIN1GRIN2BCYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | UNIV YALE (US) | 2023-07-27 | — | — | US | disclosed |
| US-20230014445-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | ASGR1, LDLR, FCGR2A | BCHE 1907/4885NOTUM 1881/4885RXRA 510/4885 |
| US-20230014445-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | BCHE 2849/4885NOTUM 2481/4885RXRA 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.