Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820296 | 0.84 | RXRA (0.58) | RXRAGRIN1GRIN2BESRRA | |
| SCHEMBL10257033 | 0.83 | NOTUM (0.56) | RXRAGRIN1GRIN2BKEAP1NFE2L2 | |
| SCHEMBL13183608 | 0.81 | CYP2A6 (0.42) | RXRAGRIN1GRIN2B | |
| SCHEMBL24908474 | 0.81 | BCHE (0.52) | RXRAGRIN1GRIN2BKEAP1NFE2L2 | |
| SCHEMBL13119830 | 0.81 | P2RX7 (0.50) | ESRRAALDH1A1L3MBTL1 | |
| SCHEMBL24010670 | 0.80 | RXRA (0.55) | RXRAGRIN1GRIN2BKEAP1NFE2L2 | |
| SCHEMBL13183607 | 0.80 | NOTUM (0.53) | RXRAGRIN1GRIN2BESRRACA12 | |
| SCHEMBL23603985 | 0.79 | NOTUM (0.59) | RXRAGRIN1GRIN2BCA12CA1 | |
| SCHEMBL23008630 | 0.79 | CYP1B1 (0.37) | RXRAGRIN1GRIN2B | |
| SCHEMBL25163608 | 0.76 | RXRA (0.43) | RXRAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | UNIV YALE (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | ASGR1, LDLR, FCGR2A | RXRA 510/4885GRIN1 2085/4885GRIN2B 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.