SCHEMBL24909790

SCHEMBL24909790

N#Cc1cc(-c2ccn(C(F)F)n2)c(O)c(C(F)(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 2/20 0.35
NTRK1 P04629 2/20 0.35
CYP19A1 P11511 1/20 0.32
TRPV4 Q9HBA0 1/20 0.32
SCN9A Q15858 3/20 0.31
XDH P47989 2/20 0.31
SLC22A12 Q96S37 2/20 0.31
CCNT1 O60563 1/20 0.31
CCNK O75909 1/20 0.31
CCNE1 P24864 1/20 0.31
CDK2 P24941 1/20 0.31
CDK7 P50613 1/20 0.31
CDK9 P50750 1/20 0.31
CCNH P51946 1/20 0.31
MNAT1 P51948 1/20 0.31
CDK12 Q9NYV4 1/20 0.31
CRHR1 P34998 1/20 0.31
AR P10275 3/20 0.31
P4HB P07237 1/20 0.31
APLNR P35414 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909950 0.82 AR (0.33) NTRK1CYP19A1TRPV4SCN9AXDH
SCHEMBL24909905 0.78 AR (0.41) NTRK1CYP19A1TRPV4XDHSLC22A12
SCHEMBL24909909 0.77 AR (0.39) NTRK1AR
SCHEMBL24910071 0.76 PDE3B (0.40) XDHSLC22A12CCNT1CCNKCCNE1
SCHEMBL24909416 0.75 CYP11B2 (0.36) CYP19A1TRPV4XDHSLC22A12AR
SCHEMBL24909796 0.73 AR (0.34) NTRK1CYP19A1TRPV4XDHSLC22A12
SCHEMBL24910103 0.73 AR (0.40) NTRK1CYP19A1TRPV4XDHSLC22A12
SCHEMBL24910087 0.72 TRPV4 (0.34) CYP19A1TRPV4XDHSLC22A12AR
SCHEMBL24909930 0.70 KIF11 (0.39) TRPV4SCN9AXDHSLC22A12AR
SCHEMBL17110737 0.68 NTRK1 (0.55) NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 TGFBR1 765/4885NTRK1 4564/4885CYP19A1 545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.