Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378971 | 1.00 | CTSK (0.44) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL9902192 | 0.88 | CTSK (0.42) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL14755238 | 0.87 | CTSK (0.41) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL14737063 | 0.86 | JAK2 (0.45) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL2377722 | 0.85 | JAK1 (0.41) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL14738121 | 0.84 | CTSK (0.53) | CTSKCTSLCTSBCTSSKMT2A | |
| SCHEMBL9101170 | 0.82 | KMT2A (0.43) | CTSKCTSLCTSBCTSSHRH2 | |
| SCHEMBL9101167 | 0.82 | KMT2A (0.43) | CTSKCTSLCTSBCTSSHRH2 | |
| SCHEMBL14738854 | 0.82 | CTSS (0.46) | CTSKCTSLCTSBCTSS | |
| SCHEMBL18212459 | 0.81 | KMT2A (0.45) | CTSKCTSLCTSBCTSSHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117145-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |