Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 9/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378971 | 0.88 | CTSK (0.44) | CTSKCTSLCTSBCTSSCA1 | |
| SCHEMBL2491119 | 0.88 | CTSK (0.44) | CTSKCTSLCTSBCTSSCA1 | |
| SCHEMBL14755238 | 0.84 | CTSK (0.41) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL14737063 | 0.83 | JAK2 (0.45) | CTSKCTSLCTSBCTSSCA1 | |
| SCHEMBL2377722 | 0.82 | JAK1 (0.41) | CTSKCTSLCTSBCTSSJAK2 | |
| SCHEMBL14738121 | 0.81 | CTSK (0.53) | CTSKCTSLCTSBCTSSTSHR | |
| SCHEMBL14738854 | 0.79 | CTSS (0.46) | CTSKCTSLCTSBCTSSTSHR | |
| SCHEMBL9279847 | 0.77 | CTSK (0.44) | CTSKCTSLCTSBCA1CA2 | |
| SCHEMBL14737016 | 0.75 | CTSK (0.43) | CTSKCTSLCTSBCTSSCA1 | |
| SCHEMBL9279883 | 0.74 | TSHR (0.41) | CTSKCTSLCTSBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |