Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488064 | 0.89 | CHRM1 (0.69) | CHRM1NAMPTTOP1 | |
| SCHEMBL2492079 | 0.87 | CHRM1 (0.57) | CHRM1MAPTTOP1 | |
| SCHEMBL2489039 | 0.83 | CHRM1 (0.74) | CHRM1MAPTCNR2TOP1 | |
| SCHEMBL2490145 | 0.81 | CHRM1 (0.59) | CHRM1MAPTTOP1 | |
| SCHEMBL2492203 | 0.81 | CHRM1 (0.61) | CHRM1TOP1 | |
| SCHEMBL2487142 | 0.81 | CHRM1 (0.48) | CHRM1NAMPTCREBBPMAPTKLKB1 | |
| SCHEMBL2487941 | 0.81 | CHRM1 (0.58) | CHRM1MAPTTOP1 | |
| SCHEMBL2485661 | 0.81 | CHRM1 (0.61) | CHRM1TOP1 | |
| SCHEMBL2488388 | 0.80 | CHRM1 (0.56) | CHRM1TOP1 | |
| SCHEMBL2488124 | 0.79 | CHRM1 (0.55) | CHRM1MAPTTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |