Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485728 | 0.89 | CHRM1 (0.47) | CHRM1NAMPTCHRM5 | |
| SCHEMBL2488459 | 0.89 | CHRM1 (0.62) | CHRM1CREBBPL3MBTL1KLKB1CHRM5 | |
| SCHEMBL2488682 | 0.87 | CHRM1 (0.57) | CHRM1CHRM5MAPT | |
| SCHEMBL2488912 | 0.83 | ROCK2 (0.46) | CHRM1 | |
| SCHEMBL2486645 | 0.81 | CHRM1 (0.42) | CHRM1PIK3CA | |
| SCHEMBL2491208 | 0.81 | CHRM1 (0.53) | CHRM1CREBBPKLKB1NAMPTMAPT | |
| SCHEMBL3234399 | 0.81 | CHRM1 (0.63) | CHRM1MAPT | |
| SCHEMBL3233811 | 0.80 | CHRM1 (0.47) | CHRM1MAPT | |
| SCHEMBL2489435 | 0.80 | CHRM1 (0.43) | CHRM1MAPT | |
| SCHEMBL2492079 | 0.79 | CHRM1 (0.57) | CHRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |