Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20522892 | 1.00 | TACR1 (0.43) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL20522837 | 1.00 | TACR1 (0.43) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL21909641 | 0.89 | ALDH1A1 (0.42) | ACHEBCHEBACE1OPRM1LMNA | |
| SCHEMBL7838918 | 0.80 | SIGMAR1 (0.46) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL2668698 | 0.79 | LTA4H (0.57) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL24649078 | 0.79 | LTA4H (0.57) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL21124809 | 0.78 | FUCA1 (0.47) | SIGMAR1ACHEDRD4MC4RDRD2 | |
| SCHEMBL2659902 | 0.76 | TACR1 (0.48) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL20522860 | 0.76 | TACR1 (0.48) | TACR1CHRM3CHRM2SIGMAR1ACHE | |
| SCHEMBL13898835 | 0.74 | CHRM3 (0.56) | CHRM3CHRM2ACHEDRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601297-B9 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC (US) | 2023-05-24 | — | — | EP | disclosed |