Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.53 |
| ▸ | FAAH | O00519 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | F12 | P00748 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | GPX4 | P36969 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241936 | 0.86 | MAPT (0.69) | TRPV1FAAHLMNAMAPTBAZ2B | |
| SCHEMBL350201 | 0.86 | TRPV1 (0.69) | TRPV1FAAHLMNAMAPTBAZ2B | |
| SCHEMBL29357331 | 0.86 | MAPT (0.69) | TRPV1FAAHLMNAMAPTBAZ2B | |
| SCHEMBL32660187 | 0.84 | ESR2 (0.46) | MTHFD2BAZ2BF12PARP1TNKS2 | |
| SCHEMBL31164770 | 0.84 | ESR2 (0.46) | MTHFD2BAZ2BF12PARP1TNKS2 | |
| SCHEMBL24914461 | 0.84 | ADORA1 (0.43) | MTHFD2TRPV1MAPTF12MAPK1 | |
| Acetic Acid SCHEMBL8718251 | 0.83 | TRPV1 (0.68) | TRPV1FAAHLMNAMAPTBAZ2B | |
| Acetic Acid SCHEMBL8714196 | 0.83 | MAPT (0.68) | TRPV1FAAHLMNAMAPTBAZ2B | |
| SCHEMBL24914511 | 0.83 | MTHFD2 (0.41) | MTHFD2TRPV1MAPTF12MAPK1 | |
| SCHEMBL24914388 | 0.82 | DDB1 (0.52) | MTHFD2MAPTF12MAPK1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023284807-A1 | COMPOUND CONTAINING TETRAHYDRONAPHTHYRIDONE OR TETRAHYDROPYRIDOPYRIMIDINONE SKELETON, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2023-01-19 | — | — | WO | disclosed |