Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852345 | 0.76 | DDB1 (0.43) | SMN1; SMN2USP2L3MBTL1GAANPSR1 | |
| SCHEMBL23013358 | 0.73 | USP2 (0.68) | SMN1; SMN2USP2L3MBTL1MAPTLMNA | |
| SCHEMBL249130 | 0.73 | TRPV1 (0.52) | SMN1; SMN2GAAMAPTLMNACYP1A2 | |
| SCHEMBL19553919 | 0.70 | HDAC6 (0.54) | SMN1; SMN2L3MBTL1GAAMAPTLMNA | |
| SCHEMBL11533429 | 0.70 | CYP2C9 (0.65) | SMN1; SMN2GAAMAPTLMNACYP1A2 | |
| SCHEMBL2755879 | 0.68 | ERCC1 (0.58) | SMN1; SMN2USP2L3MBTL1GAAMAPT | |
| SCHEMBL4102507 | 0.67 | KMT2A (0.66) | L3MBTL1GAAMAPTMEN1ALDH1A1 | |
| SCHEMBL21815373 | 0.67 | ALDH1A1 (0.53) | USP2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL23830040 | 0.67 | MAPT (0.64) | SMN1; SMN2L3MBTL1GAAMAPTCYP1A2 | |
| SCHEMBL258716 | 0.67 | CYP2C9 (0.62) | SMN1; SMN2MAPTCYP1A2CYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097410-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2010-09-02 | — | — | WO | disclosed |