SCHEMBL24914948

SCHEMBL24914948

C=CCN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1P

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 2/20 0.34
KCNK9 Q9NPC2 2/20 0.34
RXFP1 Q9HBX9 5/20 0.33
TSHR P16473 1/20 0.32
PTGES O14684 1/20 0.31
KCNJ11 Q14654 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CTSS P25774 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24914763 0.91 KCNK3 (0.35) KCNK3KCNK9RXFP1TSHRPTGES
SCHEMBL24914954 0.82 RXFP1 (0.37) RXFP1PTGESKCNJ11CTSS
SCHEMBL24914860 0.82 RXFP1 (0.39) RXFP1KCNJ11
SCHEMBL24914495 0.81 PTGES (0.31) PTGESCTSS
SCHEMBL24914632 0.80 PTGES (0.30) PTGESCTSS
SCHEMBL24914852 0.80 CTSS (0.32) KCNJ11CTSS
SCHEMBL24914947 0.79 KCNK3 (0.38) KCNK3KCNK9RXFP1TSHRSMN1; SMN2
SCHEMBL24914808 0.78 CTSS (0.37) KCNK3KCNK9RXFP1PTGESCTSS
SCHEMBL24914496 0.78 POLQ (0.38) KCNK3KCNK9RXFP1PTGESCTSS
SCHEMBL24914554 0.78 CTSS (0.39) RXFP1PTGESCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023284645-A1 AMIDE COMPOUND AND USE THEREOF 沈阳化工大学 2023-01-19 WO disclosed