Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 8/20 | 0.52 |
| ▸ | ACE | P12821 | 8/20 | 0.52 |
| ▸ | CPA1 | P15085 | 6/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26170340 | 0.88 | MME (0.53) | MMEACECPA1ACE2CYP3A4 | |
| SCHEMBL7509632 | 0.87 | MME (0.56) | MMEACECPA1ACE2CYP3A4 | |
| SCHEMBL26174647 | 0.79 | MME (0.56) | MMEACECPA1ACE2CYP3A4 | |
| SCHEMBL5967963 | 0.78 | MMP1 (0.43) | MMEACECPA1ACE2MMP9 | |
| SCHEMBL14407328 | 0.77 | CYP3A4 (0.65) | CYP3A4MAPK1MMP2MMP1MMP3 | |
| SCHEMBL15314129 | 0.77 | CYP3A4 (0.65) | CYP3A4MAPK1MMP2MMP1MMP3 | |
| SCHEMBL15314108 | 0.77 | CYP3A4 (0.65) | CYP3A4MAPK1MMP2MMP1MMP3 | |
| SCHEMBL5886609 | 0.75 | MMP1 (0.48) | MMP9MMP2MMP8MMP1MMP14 | |
| SCHEMBL13986869 | 0.75 | MMP1 (0.48) | MMP9MMP2MMP8MMP1MMP14 | |
| SCHEMBL24899346 | 0.75 | MMP3 (0.56) | MMEACECPA1ACE2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059472-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2023004240-A1 | MACROCYLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-26 | — | — | WO | disclosed |