Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 9/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923662 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTGAAMETAP2HTR6 | |
| SCHEMBL24916498 | 0.90 | KDM4E (0.49) | SMN1; SMN2MAPTGAAMETAP2CYP2D6 | |
| SCHEMBL29923592 | 0.90 | KDM4E (0.49) | SMN1; SMN2MAPTGAAMETAP2CYP2D6 | |
| SCHEMBL24916132 | 0.90 | KDM4E (0.42) | SMN1; SMN2MAPTGAAMETAP2HTR6 | |
| SCHEMBL29923190 | 0.89 | KDM4E (0.51) | SMN1; SMN2MAPTGAAMETAP2CYP2D6 | |
| SCHEMBL24916335 | 0.89 | KDM4E (0.51) | SMN1; SMN2MAPTGAAMETAP2CYP2D6 | |
| SCHEMBL29923685 | 0.87 | HTT (0.48) | SMN1; SMN2MAPTMETAP2KDM4EALDH1A1 | |
| SCHEMBL24915852 | 0.87 | HTT (0.48) | SMN1; SMN2MAPTMETAP2KDM4EALDH1A1 | |
| SCHEMBL24916127 | 0.85 | ALDH1A1 (0.48) | SMN1; SMN2MAPTHTR6KDM4EALDH1A1 | |
| SCHEMBL24916141 | 0.85 | ALDH1A1 (0.40) | SMN1; SMN2MAPTGAACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | SMN1; SMN2 2582/4885MAPT 1413/4885GAA 3980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.