Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25659961 | 0.82 | ENPP2 (0.49) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL6799198 | 0.81 | ENPP2 (0.48) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL9669534 | 0.81 | ENPP2 (0.48) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL24915808 | 0.81 | ENPP2 (0.51) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL1239052 | 0.81 | ENPP2 (0.51) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| Hydrochloric Acid SCHEMBL26962445 | 0.79 | ENPP2 (0.50) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| Hydrochloric Acid SCHEMBL22750345 | 0.79 | ENPP2 (0.50) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| Hydrochloric Acid SCHEMBL11645437 | 0.79 | ENPP2 (0.50) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL24915659 | 0.78 | ENPP2 (0.46) | ENPP2HTR1AHTR2BSIGMAR1HTR7 | |
| SCHEMBL24915967 | 0.78 | ENPP2 (0.46) | ENPP2HTR1AHTR2BSIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-B1 | WDR5 INHIBITORS AND MODULATORS | UNIV VANDERBILT (US) | 2024-03-20 | — | — | EP | disclosed |
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-26 | — | — | US | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | ENPP2 2798/4885HTR1A 4192/4885HTR2B 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.