Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311833 | 0.92 | MEN1 (0.53) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL6606900 | 0.89 | NPC1 (0.52) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL310741 | 0.87 | ATAD2 (0.58) | NPC1MAPTKMT2AATAD2POLB | |
| SCHEMBL7100948 | 0.83 | NPC1 (0.66) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL1997115 | 0.83 | NPC1 (0.70) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL8413415 | 0.83 | HTT (0.56) | NPC1MAPTMEN1KMT2APOLB | |
| SCHEMBL18496690 | 0.81 | MEN1 (0.60) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL29727627 | 0.81 | MEN1 (0.60) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL18172331 | 0.81 | POLB (0.47) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL6162376 | 0.80 | ALOX5 (0.59) | MAPTMEN1KMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445868-A2 | NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES | F. Hoffmann-La Roche AG (CH) | 2012-05-02 | — | — | EP | disclosed |
| EP-2379518-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010149578-A2 | NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | disclosed |
| EP-2225213-A1 | TRIAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND /OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| WO-2010069794-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| WO-2009077366-A1 | TRIAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND /OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |