Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MPI | P34949 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916357 | 0.86 | MAPT (0.47) | MTNR1BDRD3ALDH1A1KDM4EMAPT | |
| SCHEMBL24916127 | 0.85 | ALDH1A1 (0.48) | MTNR1BDRD3APPLRRK2ALDH1A1 | |
| SCHEMBL24915841 | 0.85 | KDM4E (0.44) | ALDH1A1KDM4EMAPTNPC1MPI | |
| SCHEMBL24915979 | 0.83 | MAPT (0.40) | MTNR1BLRRK2ALDH1A1KDM4EMAPT | |
| SCHEMBL24916359 | 0.83 | HTT (0.46) | ALDH1A1KDM4EMAPTNPC1MPI | |
| SCHEMBL24915957 | 0.82 | LRRK2 (0.45) | DRD3LRRK2ALDH1A1KDM4EMAPT | |
| SCHEMBL24916363 | 0.81 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL24915839 | 0.81 | LRRK2 (0.39) | MTNR1BLRRK2ALDH1A1KDM4EMAPT | |
| SCHEMBL24916360 | 0.79 | KDM4E (0.43) | ALDH1A1KDM4EMAPTNPC1MPI | |
| SCHEMBL24916430 | 0.77 | NSD2 (0.39) | MTNR1BKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | MTNR1B 3677/4885DRD3 4481/4885APP 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.