Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 10/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923978 | 1.00 | WDR5 (0.42) | WDR5PDE3BPDE3ANTRK1GAA | |
| SCHEMBL29923684 | 0.89 | WDR5 (0.40) | WDR5PDE3BPDE3ANTRK1BRD4 | |
| SCHEMBL24916095 | 0.87 | WDR5 (0.39) | WDR5ALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL30054457 | 0.82 | WDR5 (0.46) | WDR5PDE3BPDE3ABRD4CREBBP | |
| SCHEMBL24916117 | 0.82 | WDR5 (0.46) | WDR5PDE3BPDE3ABRD4CREBBP | |
| SCHEMBL27167325 | 0.82 | WDR5 (0.44) | WDR5PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL24915754 | 0.80 | WDR5 (0.46) | WDR5PDE3BPDE3ABRD4 | |
| SCHEMBL30055237 | 0.80 | WDR5 (0.46) | WDR5PDE3BPDE3ABRD4 | |
| SCHEMBL29923286 | 0.78 | PARP1 (0.48) | WDR5PDE3BPDE3A | |
| SCHEMBL24916292 | 0.75 | WDR5 (0.54) | WDR5PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-B1 | WDR5 INHIBITORS AND MODULATORS | UNIV VANDERBILT (US) | 2024-03-20 | — | — | EP | disclosed |
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | WDR5 1/4885PDE3B 4281/4885PDE3A 4324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.