Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.48 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.41 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 6/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30190535 | 0.85 | PARP1 (0.45) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL29923684 | 0.81 | WDR5 (0.40) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL30055237 | 0.81 | WDR5 (0.46) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL24915754 | 0.81 | WDR5 (0.46) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL30054457 | 0.81 | WDR5 (0.46) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL24916117 | 0.81 | WDR5 (0.46) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL24916099 | 0.78 | WDR5 (0.42) | WDR5PDE3BPDE3A | |
| SCHEMBL29923978 | 0.78 | WDR5 (0.42) | WDR5PDE3BPDE3A | |
| SCHEMBL29697978 | 0.76 | PARP1 (0.48) | PARP1PARP10PARP11PARP15PARP14 | |
| SCHEMBL24916292 | 0.75 | WDR5 (0.54) | PARP1PARP10PARP11WDR5PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999716-B2 | WDR5 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2024-06-04 | — | — | US | disclosed |
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-26 | — | — | US | disclosed |
| US-20230012362-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2023-01-12 | — | — | US | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026466-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | PARP1 1578/4885PARP10 482/4885PARP11 510/4885 |
| US-20230012362-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR77 | PARP1 1588/4885PARP10 501/4885PARP11 487/4885 |
| US-11999716-B2 | WDR5 inhibitors and modulators | WDR5, WDR1, WDR3 | PARP1 1697/4885PARP10 555/4885PARP11 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.