SCHEMBL249197

SCHEMBL249197

C[Si](C)(C)C#Cc1cccc2c1c(C=O)cn2C(=O)O

nearest known ligand 0.32

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CREBBP Q92793 1/20 0.32
POLB P06746 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
IMPDH2 P12268 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15902473 0.76 ALDH1A1 (0.39) ALDH1A1MEN1TSHRKMT2APOLB
SCHEMBL251571 0.74 HTT (0.33) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL1229812 0.73 ERN1 (0.42) ALDH1A1MEN1CYP3A4KMT2A
SCHEMBL20503064 0.73 CYP2A6 (0.41) ALDH1A1KDM4EMEN1KMT2APOLB
SCHEMBL15901985 0.73 ALDH1A1 (0.36) ALDH1A1KDM4EMEN1TSHRKMT2A
SCHEMBL15902384 0.72 ERN1 (0.46) ALDH1A1KDM4EMAPTTSHRTDP1
SCHEMBL249361 0.72 ERN1 (0.33) ALDH1A1MEN1KMT2APOLBTDP1
SCHEMBL20503055 0.69 RORC (0.40) CYP3A4CYP2C9CYP2C19
SCHEMBL709085 0.68 KMT2A (0.44) ALDH1A1KDM4EMEN1CYP1A2CYP3A4
SCHEMBL15902268 0.68 KDM4E (0.47) ALDH1A1KDM4EMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012001308-A9 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-03-22 WO disclosed
WO-2012001308-A1 METHOD FOR SYNTHESIZING ERGOLINE ALKALOIDS FROM INDOLIC BICYCLIC COMPOUNDS BY DOUBLE CYCLIZATION, RESULTING MATERIALS, AND INTERMEDIATE MATERIALS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-01-05 WO disclosed