Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7882554 | 0.83 | MAPK1 (0.61) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL14827254 | 0.82 | P4HTM (0.51) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL31036563 | 0.82 | MAPK1 (0.59) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL987417 | 0.82 | MAPK1 (0.59) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL18489381 | 0.82 | MAPK1 (0.59) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL9034066 | 0.81 | RAB9A (0.43) | MAPK1RAB9ANPC1ALDH1A1TSHR | |
| SCHEMBL2677914 | 0.81 | ALDH1A1 (0.44) | RAB9ANPC1ALDH1A1TSHRKMT2A | |
| SCHEMBL29695096 | 0.81 | MAPK1 (0.57) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL24724201 | 0.81 | MAPK1 (0.57) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL18758445 | 0.81 | MAPK1 (0.57) | MAPK1RAB9ANPC1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | PIK3CA, PIK3CG, PIK3CD | MAPK1 214/4885RAB9A 422/4885NPC1 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.