Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557710 | 0.79 | DEGS1 (0.60) | EPHX2DEGS1MEN1KMT2AKDM6B | |
| SCHEMBL13934555 | 0.76 | EPHX2 (0.53) | EPHX2DEGS1MEN1KMT2AHDAC8 | |
| SCHEMBL822338 | 0.75 | TSHR (0.59) | EPHX2MEN1KMT2AHDAC8HDAC6 | |
| Benzene SCHEMBL11566961 | 0.74 | EPHX2 (0.76) | EPHX2MEN1KMT2AKDM6BKDM4D | |
| SCHEMBL2205445 | 0.74 | EPHX2 (0.76) | EPHX2MEN1KMT2AKDM6BKDM4D | |
| SCHEMBL1516167 | 0.74 | EPHX2 (1.00) | EPHX2MEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL2489636 | 0.74 | ALDH1A1 (0.42) | EPHX2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4203468 | 0.73 | EPHX2 (0.54) | EPHX2DEGS1MEN1KMT2AHDAC8 | |
| SCHEMBL30378242 | 0.73 | EPHX2 (0.54) | EPHX2DEGS1MEN1KMT2AHDAC8 | |
| SCHEMBL16061776 | 0.73 | EPHX2 (0.50) | EPHX2DEGS1MEN1KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325481-A1 | COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO KIT AND PDGFR | Blueprint Medicines Corporation (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017019442-A1 | COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO KIT AND PDGFR | BLUEPRINT MEDICINES CORPORATION (US) | 2017-02-02 | — | — | WO | disclosed |
| EP-2550257-A1 | PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES | Lead Discovery Center GmbH (DE) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011116951-A1 | PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES | LEAD DISCOVERY CENTER GMBH (DE) | 2011-09-29 | — | — | WO | disclosed |