Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | PPARA | Q07869 | 4/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371037 | 0.82 | CES2 (0.43) | TDP1CYP3A4PSEN1PSEN2APH1B | |
| SCHEMBL3978958 | 0.80 | TP53 (0.48) | TDP1LMNATP53HTTKMT2A | |
| SCHEMBL12615183 | 0.79 | APLNR (0.41) | LMNAHTTERN1KMT2AOPRM1 | |
| SCHEMBL20551400 | 0.79 | MDM2 (0.38) | MDM2KCNH2TDP1PPARGPPARA | |
| SCHEMBL27741876 | 0.79 | LMNA (0.40) | MDM2KCNH2TDP1PPARGPPARA | |
| Hydrochloric Acid SCHEMBL3248108 | 0.78 | LMNA (0.39) | MDM2KCNH2TDP1PPARGPPARA | |
| SCHEMBL16093965 | 0.77 | TSHR (0.45) | TDP1LMNATP53HTTERN1 | |
| SCHEMBL27844615 | 0.77 | KCNH2 (0.39) | MDM2KCNH2TDP1PPARGPPARA | |
| SCHEMBL13278281 | 0.75 | CNR2 (0.38) | MDM2KCNH2PPARGPPARAERN1 | |
| SCHEMBL5075505 | 0.74 | CES2 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379557-A1 | AMINO PYRAZOLE COMPOUND | Eli Lilly and Company (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010074947-A1 | AMINO PYRAZOLE COMPOUND | ELI LILLY AND COMPANY (US) | 2010-07-01 | — | — | WO | disclosed |