Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5444260 | 0.75 | RAB9A (0.42) | MAPTALDH1A1HPGDNOTUMTSHR | |
| SCHEMBL14031552 | 0.75 | CYP2C19 (0.37) | MAPTALDH1A1TSHRCYP2C19NPC1 | |
| SCHEMBL24921990 | 0.75 | MAPT (0.42) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL5417649 | 0.74 | NOTUM (0.46) | MAPTNOTUMTSHR | |
| SCHEMBL24921991 | 0.74 | ALDH1A1 (0.47) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921176 | 0.73 | NOTUM (0.54) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL25693362 | 0.73 | NOTUM (0.44) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24920826 | 0.73 | CYP2C19 (0.36) | ALDH1A1HPGDCYP2C19NPC1RAB9A | |
| SCHEMBL25986790 | 0.73 | TSHR (0.37) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24920820 | 0.72 | CYP2C19 (0.38) | MAPTCYP2C19NPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |