Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921973 | 0.76 | MAPT (0.42) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921992 | 0.76 | MAPT (0.42) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921991 | 0.75 | ALDH1A1 (0.47) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921610 | 0.75 | NOTUM (0.58) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24920829 | 0.75 | MAPT (0.41) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921604 | 0.75 | NOTUM (0.50) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24920840 | 0.75 | MAPT (0.45) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921517 | 0.72 | OXTR (0.36) | SIRT6NPC1RAB9AKMT2ATLR8 | |
| SCHEMBL24921176 | 0.71 | NOTUM (0.54) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921161 | 0.70 | MAPT (0.56) | MAPTALDH1A1HPGDMAPK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |