Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920725 | 0.90 | NPC1 (0.33) | NR1I2HSD11B1ALOX5APNPC1RAB9A | |
| SCHEMBL24920877 | 0.82 | NPC1 (0.35) | HSD11B1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24920886 | 0.82 | HSD11B1 (0.38) | HSD11B1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24920852 | 0.82 | NPC1 (0.34) | HSD11B1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24921645 | 0.81 | RAB9A (0.35) | ALOX5APNPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL24920850 | 0.81 | ALOX5AP (0.35) | HSD11B1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24920884 | 0.81 | ALOX5AP (0.35) | ALOX5APNPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL24920854 | 0.81 | ALOX5AP (0.34) | HSD11B1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24920911 | 0.80 | LMNA (0.35) | ALOX5APNPC1RAB9ASMN1; SMN2CASP3 | |
| SCHEMBL24921215 | 0.79 | NPC1 (0.40) | HSD11B1ALOX5APNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |