Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL538308 | 0.98 | ADRA2A (0.45) | CA2ADRA2AADRA2BADRA2CTDP1 | |
| SCHEMBL3785285 | 0.90 | AOC3 (0.45) | SPHK1NPC1CYP3A4CYP2D6NOS1 | |
| Nitric Acid SCHEMBL2076135 | 0.88 | TSHR (0.49) | CA2CA1CA12CA4CA6 | |
| SCHEMBL13911596 | 0.84 | TAAR1 (0.48) | ADRA2ATDP1SPHK1NPC1CYP3A4 | |
| SCHEMBL20553484 | 0.83 | PRSS1 (0.54) | CA2ADRA2AADRA2BADRA2CCA1 | |
| SCHEMBL12514072 | 0.82 | AOC3 (0.44) | CA2ADRA2AADRA2BADRA2CCA1 | |
| SCHEMBL7523474 | 0.82 | SPHK1 (0.39) | SPHK1NPC1CYP3A4CYP2D6NOS1 | |
| Hydrochloric Acid SCHEMBL6157588 | 0.82 | PRSS1 (0.52) | CA2ADRA2AADRA2BADRA2CCA1 | |
| SCHEMBL1743186 | 0.81 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CF2PRSS1 | |
| SCHEMBL13785815 | 0.81 | AOC3 (0.40) | SPHK1NPC1CYP3A4CYP2D6NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| CN-102325755-B | Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds | ARQULE INC | 2015-07-01 | — | — | CN | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| CN-102325755-A | Substituted 5,6-dihydro-6-phenyl benzo [F] isoquinoline 99.9-2-amine compound | ARQULE INC | 2012-01-18 | — | — | CN | disclosed |
| EP-2379506-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-0584066-A4 | ANTI-THROMBOTIC PEPTIDE AND PSEUDOPEPTIDE DERIVATIVES. | RHONE POULENC RORER INT (US) | 1994-10-12 | — | — | EP | disclosed |
| EP-0584066-A1 | ANTI-THROMBOTIC PEPTIDE AND PSEUDOPEPTIDE DERIVATIVES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992018117-A1 | ANTI-THROMBOTIC PEPTIDE AND PSEUDOPEPTIDE DERIVATIVES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | CA2 3145/4885ADRA2A 809/4885ADRA2B 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.