⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18365974 | 0.80 | AOC3 (0.30) | — | |
| SCHEMBL23278589 | 0.78 | PER2 (0.32) | — | |
| SCHEMBL18365971 | 0.77 | RIPK1 (0.34) | — | |
| SCHEMBL24928276 | 0.76 | — | — | |
| SCHEMBL18377671 | 0.75 | CYP19A1 (0.38) | — | |
| SCHEMBL17969848 | 0.73 | EED (0.36) | — | |
| SCHEMBL26299369 | 0.73 | PDE10A (0.32) | — | |
| SCHEMBL18365975 | 0.68 | CYP11B2 (0.39) | — | |
| SCHEMBL13057508 | 0.66 | HTR2A (0.33) | — | |
| SCHEMBL24928602 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240190831-A1 | TRANSTHYRETIN STABILIZING COMPOUNDS | PROTEGO BIOPHARMA, INC. | 2024-06-13 | — | — | US | disclosed |
| WO-2023009585-A2 | TRANSTHYRETIN STABILIZING COMPOUNDS | PROTEGO BIOPHARMA, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2023009585-A2 | TRANSTHYRETIN STABILIZING COMPOUNDS | PROTEGO BIOPHARMA, INC. (US) | 2023-02-02 | — | — | WO | disclosed |