Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30153337 | 1.00 | BRD4 (0.44) | BRD4ACLYPDE4APDE4BPDE4C | |
| SCHEMBL30845569 | 0.94 | BRD4 (0.43) | BRD4ACLYPDE4APDE4BPDE4C | |
| SCHEMBL30153373 | 0.94 | BRD4 (0.43) | BRD4ACLYPDE4APDE4BPDE4C | |
| SCHEMBL31198427 | 0.87 | ACLY (0.41) | BRD4ACLYERAP1RAD52PIK3CA | |
| SCHEMBL24928651 | 0.87 | ACLY (0.38) | BRD4ACLYPDE4APDE4BPDE4C | |
| SCHEMBL24928655 | 0.87 | ACLY (0.41) | BRD4ACLYERAP1RAD52PIK3CA | |
| SCHEMBL31198500 | 0.87 | ACLY (0.38) | BRD4ACLYPDE4APDE4BPDE4C | |
| SCHEMBL24928843 | 0.85 | ACLY (0.38) | BRD4ACLYTDP1ERAP1RAD52 | |
| SCHEMBL30153324 | 0.85 | ACLY (0.38) | BRD4ACLYTDP1ERAP1RAD52 | |
| SCHEMBL22637408 | 0.81 | ACLY (0.44) | BRD4ACLYTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007188-A1 | PHENYL-SULFAMOYL-BENZOIC ACID DERIVATIVES AS ERAP1- MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2023-02-02 | — | — | WO | disclosed |