Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30361460 | 0.84 | HPGD (0.47) | HPGDRXRAVNN1SMN1; SMN2LRRK2 | |
| SCHEMBL30361485 | 0.81 | HPGD (0.46) | HPGDRXRAVNN1LRRK2ADORA2A | |
| SCHEMBL24928922 | 0.81 | HPGD (0.46) | HPGDRXRAVNN1LRRK2ADORA2A | |
| SCHEMBL30947683 | 0.80 | HPGD (0.50) | HPGDRXRAVNN1SMN1; SMN2LRRK2 | |
| SCHEMBL24463691 | 0.80 | HPGD (0.53) | HPGDRXRAVNN1SMN1; SMN2LRRK2 | |
| SCHEMBL24928924 | 0.79 | HPGD (0.52) | HPGDRXRAVNN1LRRK2ADORA2A | |
| SCHEMBL30361451 | 0.79 | HPGD (0.52) | HPGDRXRAVNN1LRRK2ADORA2A | |
| SCHEMBL30361471 | 0.79 | HPGD (0.52) | HPGDRXRAVNN1ADRA1ASMN1; SMN2 | |
| SCHEMBL24929596 | 0.78 | HPGD (0.57) | HPGDRXRAVNN1LRRK2ALDH1A1 | |
| SCHEMBL24929885 | 0.77 | HPGD (0.51) | HPGDSMN1; SMN2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |