Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | GALR1 | P47211 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22053004 | 0.78 | ALDH1A1 (0.49) | METAP2 | |
| SCHEMBL4345238 | 0.78 | IDO1 (0.50) | — | |
| SCHEMBL3754960 | 0.78 | ENPP2 (0.50) | METAP2 | |
| SCHEMBL12127268 | 0.78 | IDO1 (0.50) | — | |
| SCHEMBL4333689 | 0.78 | IDO1 (0.46) | METAP2MAPK14 | |
| SCHEMBL30311721 | 0.78 | ALDH1A1 (0.49) | METAP2 | |
| SCHEMBL2491046 | 0.76 | MTOR (0.45) | — | |
| SCHEMBL12130494 | 0.74 | — | — | |
| SCHEMBL21257451 | 0.74 | IDO1 (0.50) | — | |
| SCHEMBL939949 | 0.74 | KMO (0.53) | KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009618-A1 | BICYCLIC PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO, INC. (US) | 2023-02-02 | — | — | WO | disclosed |