Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN1 | Q92952 | 2/20 | 0.42 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.42 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.42 |
| ▸ | MECP2 | P51608 | 1/20 | 0.42 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492728 | 0.78 | PDE10A (0.38) | GCKCDK5CDK5R1NPC1RAB9A | |
| SCHEMBL190426 | 0.77 | KCNN1 (0.61) | KCNN1KCNN2KCNN3MECP2MBD2 | |
| SCHEMBL2493333 | 0.75 | KDR (0.43) | CDK5CDK5R1MEN1NPC1RAB9A | |
| SCHEMBL12305708 | 0.72 | GCK (0.47) | GCKTGFBR1MEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL191778 | 0.71 | GCK (0.47) | GCKTGFBR1MEN1NPC1RAB9A | |
| SCHEMBL190602 | 0.69 | NPC1 (0.58) | KCNN1KCNN2KCNN3MECP2MBD2 | |
| SCHEMBL2489158 | 0.69 | TGFBR1 (0.37) | KCNN1KCNN2KCNN3MECP2MBD2 | |
| SCHEMBL6372588 | 0.68 | MECP2 (0.55) | KCNN1KCNN2KCNN3MECP2MBD2 | |
| SCHEMBL30745793 | 0.68 | GRM4 (0.63) | KCNN1KCNN2KCNN3MECP2MBD2 | |
| SCHEMBL5174932 | 0.68 | GRM4 (0.63) | KCNN1KCNN2KCNN3MECP2MBD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022222-B2 | Glucokinase activators | ARRAY BIOPHARMA, INC. (US) | 2011-09-20 | — | — | US | disclosed |