Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563905 | 0.89 | JAK2 (0.42) | ALDH1A1NPC1RAB9AJAK2JAK1 | |
| SCHEMBL24932138 | 0.82 | RAB9A (0.53) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL24931577 | 0.81 | ABL1 (0.43) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL30899659 | 0.81 | HSD17B10 (0.49) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL15000512 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL19699501 | 0.77 | MAPK8 (0.45) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL29563807 | 0.76 | HRH3 (0.42) | ALDH1A1LMNASMN1; SMN2HRH3ACACB | |
| SCHEMBL24932361 | 0.75 | GCK (0.69) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL19699568 | 0.71 | ALDH1A1 (0.39) | ALDH1A1MAPTNPC1RAB9ATP53 | |
| SCHEMBL19699567 | 0.71 | ALDH1A1 (0.39) | ALDH1A1MAPTNPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901280-B | MrgprX2 antagonists and uses thereof | 德米拉公司 | 2025-05-27 | — | — | CN | disclosed |
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | DERMIRA, INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | DERMIRA, INC. | 2023-01-26 | — | — | US | disclosed |
| EP-4054570-A1 | MRGPRX2 ANTAGONISTS AND USES THEREOF | Dermira, Inc (US) | 2022-09-14 | — | — | EP | disclosed |
| CN-114901280-A | MrgprX2 antagonists and uses thereof | 德米拉公司 | 2022-08-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027929-A1 | MrgprX2 Antagonists and Uses Thereof | MRGPRX2, MRGPRX1, MRGPRX4 | ALDH1A1 2645/4885MAPT 4178/4885NPC1 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.