Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30240861 | 1.00 | CYP11B2 (0.39) | CYP11B2CYP11B1PRMT5WDR77PIK3CB | |
| SCHEMBL24933559 | 0.81 | CYP11B2 (0.39) | CYP11B2CYP11B1PRMT5WDR77CYP2A6 | |
| SCHEMBL17820615 | 0.78 | CYP11B2 (0.42) | CYP11B2CYP11B1GSK3BCYP2A6NOS3 | |
| SCHEMBL23647871 | 0.76 | DRD2 (0.47) | PRMT5WDR77PIK3CBPRKDCATM | |
| SCHEMBL29865963 | 0.76 | DRD2 (0.47) | PRMT5WDR77PIK3CBPRKDCATM | |
| SCHEMBL20401106 | 0.75 | ALOX5 (0.40) | PRMT5WDR77PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30227495 | 0.74 | PRMT5 (0.36) | CYP11B2CYP11B1PRMT5WDR77PRKAB2 | |
| SCHEMBL25816434 | 0.71 | CYP11B1 (0.38) | CYP11B2CYP11B1CCNA2CDK2GRK2 | |
| SCHEMBL9156445 | 0.70 | CYP11B1 (0.40) | CYP11B2CYP11B1CYP2A6NOS3NOS1 | |
| SCHEMBL31371169 | 0.69 | PRMT5 (0.38) | PRMT5WDR77MAPK1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |