Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 9/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933359 | 0.85 | HSD17B2 (0.50) | HSD17B2HSD17B1AKR1C3AKR1C2 | |
| SCHEMBL24932964 | 0.83 | PARP10 (0.43) | HSD17B2HSD17B1PTPN5 | |
| SCHEMBL24933605 | 0.83 | HSD17B2 (0.41) | HSD17B2HSD17B1PARP1 | |
| SCHEMBL24933312 | 0.83 | BTK (0.42) | HSD17B2HSD17B1CDK5 | |
| SCHEMBL24933339 | 0.82 | HSD17B1 (0.41) | HSD17B2HSD17B1PARP1CDK5CDK5R1 | |
| SCHEMBL24932950 | 0.82 | HSD17B2 (0.52) | HSD17B2HSD17B1PARP1 | |
| SCHEMBL24933053 | 0.81 | KDM4E (0.44) | HSD17B2HSD17B1PARP1 | |
| SCHEMBL24933771 | 0.81 | IKBKB (0.42) | HSD17B2HSD17B1PARP1CDK5CDK5R1 | |
| SCHEMBL24933343 | 0.80 | HSD17B1 (0.39) | HSD17B2HSD17B1AKR1C3AKR1C2PARP1 | |
| SCHEMBL24933335 | 0.80 | HSD17B2 (0.44) | HSD17B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | claimed |
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |