Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23367850 | 0.83 | MEN1 (0.62) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL15604757 | 0.82 | RAB9A (0.66) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL23367946 | 0.82 | F2R (0.70) | F2RNPC1RAB9AALDH1A1POLB | |
| SCHEMBL11918972 | 0.81 | TP53 (0.54) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL27972423 | 0.81 | MEN1 (0.70) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL882809 | 0.81 | F2R (1.00) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8269644 | 0.80 | GAA (0.61) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15014130 | 0.80 | TAS1R3 (0.54) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12259165 | 0.79 | KMT2A (0.72) | F2RSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL6819098 | 0.79 | KMT2A (0.58) | F2RSMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |