Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218220 | 0.86 | MAPT (0.43) | MAPTHTTPSEN1PSEN2APH1B | |
| SCHEMBL6654340 | 0.76 | LMNA (0.58) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24933447 | 0.75 | DDB1 (0.46) | MAPTHTTMEN1KMT2ANPC1 | |
| SCHEMBL16201990 | 0.74 | PKM (0.54) | MAPTHTTMEN1KMT2ANPC1 | |
| SCHEMBL6708174 | 0.74 | PTPN1 (0.50) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14652405 | 0.74 | MAPT (0.53) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12147577 | 0.74 | PTPN1 (0.44) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17652044 | 0.73 | SMN1; SMN2 (0.64) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5515918 | 0.73 | PSEN1 (0.49) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4598237 | 0.73 | PSEN1 (0.49) | MAPTPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |