Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | OXTR | P30559 | 4/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934239 | 0.75 | MAPT (0.44) | DDB1CRBNKMT2APOLBHTT | |
| SCHEMBL16201990 | 0.72 | PKM (0.54) | DDB1CRBNKMT2AHTTMEN1 | |
| SCHEMBL5880760 | 0.71 | RAB9A (0.53) | POLBALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL1880183 | 0.68 | HRH3 (0.61) | KMT2AMEN1 | |
| SCHEMBL599185 | 0.68 | HRH3 (0.54) | ALDH1A1ALOX15TP53MAPTTDP1 | |
| SCHEMBL1870561 | 0.68 | DDB1 (0.41) | DDB1CRBNOXTRAVPR1AAVPR2 | |
| SCHEMBL2664263 | 0.68 | MAOB (0.46) | KMT2APOLBMEN1ALDH1A1TDP1 | |
| SCHEMBL10938284 | 0.68 | SMN1; SMN2 (0.55) | KMT2AMEN1ALDH1A1ALOX15NPC1 | |
| SCHEMBL15420757 | 0.68 | DDB1 (0.41) | DDB1CRBNOXTRAVPR1AAVPR2 | |
| SCHEMBL1875739 | 0.68 | HRH3 (0.63) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |