Phenylmethylsulfonylfluoride

Phenylmethylsulfonylfluoride

SCHEMBL24938

O=S(=O)(F)Cc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRSS1 P07477 2/20 1.00
PRSS2 P07478 2/20 1.00
PRSS3 P35030 2/20 1.00
FAAH O00519 1/20 1.00
ELANE P08246 1/20 1.00
PRTN3 P24158 1/20 1.00
CA2 P00918 5/20 0.58
CA1 P00915 3/20 0.58
CA9 Q16790 2/20 0.58
CA5A P35218 1/20 0.58
MMP1 P03956 1/20 0.52
MMP2 P08253 1/20 0.52
MMP9 P14780 1/20 0.52
MMP8 P22894 1/20 0.52
MMP13 P45452 1/20 0.52
KMT2A Q03164 2/20 0.50
HSP90AA1 P07900 1/20 0.47
F2 P00734 1/20 0.47
TSHR P16473 3/20 0.45
HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenylmethylsulfonylfluoride SCHEMBL3965163 1.00 PRSS1 (1.00) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL438262 0.97 PRSS1 (0.95) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL11616357 0.97 PRSS1 (0.95) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL4869292 0.97 PRSS1 (0.95) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL28507854 0.93 PRSS1 (0.86) PRSS1PRSS2PRSS3FAAHELANE
(Phenylsulfonyl)Benzene SCHEMBL11134052 0.89 PRSS1 (0.79) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL7987561 0.89 PRSS1 (0.79) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL11618045 0.89 PRSS1 (0.79) PRSS1PRSS2PRSS3FAAHELANE
SCHEMBL6459388 0.86 FAAH (0.75) PRSS1PRSS2PRSS3FAAHELANE
Phenylmethylsulfonylfluoride SCHEMBL10796968 0.82 PRSS1 (0.68) PRSS1PRSS2PRSS3FAAHELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 78287 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118831066-B Medicine-carrying bionic nano bait based on genetic engineering and preparation method and application thereof ZHEJIANG UNIVERSITY (CN) 2026-05-26 CN claimed
CN-122081365-A Alpha-hemolysin recombinant protein and prokaryotic expression method thereof 2026-05-26 CN claimed
CN-122060721-A Nuclear extraction reagent and preparation method and application thereof 北京爱普汇生物科技有限公司 2026-05-19 CN claimed
CN-122031651-A Stem cell-based knee joint injury repairing agent and preparation method and application thereof 深圳伊甸赛尔生物科技有限公司 2026-05-15 CN claimed
CN-122012424-A Preparation method of UrdA urocanic acid reductase 复旦大学附属中山医院 2026-05-12 CN claimed
US-20260125640-A1 ACELLULAR PLACENTAL PREPARATIONS PLAKOUS THERAPEUTICS INC (US) 2026-05-07 US claimed
US-12590120-B2 Materials and methods for isolating self-antigen polypeptides Impact Proteomics (US) 2026-03-31 US claimed
CN-121570436-A Bionic black phosphorus nanomaterial and preparation and application thereof 华中科技大学同济医学院附属协和医院 2026-02-27 CN claimed
CN-121574074-A Preparation method of benzyl sulfonyl fluoride compound 江南大学 2026-02-27 CN claimed
US-12540339-B2 Germacrene synthase SgTPS7 protein, coding gene and use in synthesis of germacrene RESEARCH INSTITUTE OF TROPICAL FORESTRY, CHINESE ACADEMY OF FORESTRY (CN) 2026-02-03 US claimed
US-4458013-A DIAGNOSIS OF PANCREATIC DISEASES DAINABOT KABUSHIKI KAISHA (JP) 1984-07-03 US claimed
EP-0107782-A1 Process for the isolation of relaxin Serono Pharmazeutische Präparate GmbH (DE) 1984-05-09 EP claimed
US-4431582-A WOUND HEALING AGENTS RESEARCH CORPORATION (US) 1984-02-14 US claimed
US-RE31517-E ETHYLENEDIAMINETETRAACETIC ACID, RADIOIMMUNOASSAY, INCUBATION, ANGIOTENSIN Fernandez de Castro, Aurora L. (US) 1984-02-07 US claimed
US-4361653-A ENZYME INHIBITORS THE GREEN CROSS CORPORATION (JP) 1982-11-30 US claimed
US-4342827-A GLYCEROL DEHYDROGENASE ENZYMES PRODUCED FROM BACILLUS STEAROTHERMOPHILUS PUBLIC HEALTH LABORATORY SERVICE, CENTER FOR APPLIED MICROBIOLOGY & RESEARCH (GB) 1982-08-03 US claimed
US-4112064-A PHENYLMETHYLSULFONYL FLUORIDE HOFFMANN-LA ROCHE INC. (US) 1978-09-05 US claimed
US-4062730-A PSEUDOMONAS FLUORESCENS Malkki, Yrjo (SF) 1977-12-13 US claimed
US-3986930-A COLORIMETRY, S-ACYL COMPOUNDS DAINIPPON PHARMACEUTICAL CO., LTD. (JA) 1976-10-19 US claimed
US-3984532-A Method for quantitative determination of renin activity in blood employing phenyl methyl sulfonyl fluoride and polyethylene glycol FERNANDEZ DE CASTRO AURORA L 1976-10-05 US claimed