SCHEMBL6459388

SCHEMBL6459388

O=S(=O)(F)Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.75
PRSS1 P07477 1/20 0.75
PRSS2 P07478 1/20 0.75
ELANE P08246 1/20 0.75
PRTN3 P24158 1/20 0.75
PRSS3 P35030 1/20 0.75
ABCC4 O15439 1/20 0.47
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
TSHR P16473 1/20 0.47
PTGS1 P23219 1/20 0.47
HTT P42858 1/20 0.47
TAAR1 Q96RJ0 2/20 0.46
CA1 P00915 5/20 0.46
CA2 P00918 5/20 0.46
CA9 Q16790 3/20 0.45
CA5A P35218 1/20 0.45
MMP13 P45452 3/20 0.44
MMP12 P39900 2/20 0.44
CA12 O43570 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenylmethylsulfonylfluoride SCHEMBL24938 0.86 PRSS1 (1.00) FAAHPRSS1PRSS2ELANEPRTN3
Phenylmethylsulfonylfluoride SCHEMBL3965163 0.86 PRSS1 (1.00) FAAHPRSS1PRSS2ELANEPRTN3
Phenylmethylsulfonylfluoride SCHEMBL438262 0.84 PRSS1 (0.95) FAAHPRSS1PRSS2ELANEPRTN3
Phenylmethylsulfonylfluoride SCHEMBL11616357 0.84 PRSS1 (0.95) FAAHPRSS1PRSS2ELANEPRTN3
Phenylmethylsulfonylfluoride SCHEMBL4869292 0.84 PRSS1 (0.95) FAAHPRSS1PRSS2ELANEPRTN3
Phenylmethylsulfonylfluoride SCHEMBL28507854 0.80 PRSS1 (0.86) FAAHPRSS1PRSS2ELANEPRTN3
SCHEMBL31540567 0.79 MMP12 (0.59) FAAHPRSS1PRSS2ELANEPRTN3
SCHEMBL31540566 0.79 MMP12 (0.59) FAAHPRSS1PRSS2ELANEPRTN3
SCHEMBL8166600 0.78 ABCC4 (0.47) FAAHPRSS1PRSS2ELANEPRTN3
SCHEMBL3630765 0.78 TAAR1 (0.52) FAAHPRSS1PRSS2ELANEPRTN3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121574074-A Preparation method of benzyl sulfonyl fluoride compound 江南大学 2026-02-27 CN disclosed
EP-1539722-A1 THIAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2005-06-15 EP disclosed
WO-2004014884-A1 THIAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2004-02-19 WO disclosed
US-5360935-A From phenylmethanesulfonyl fluorides and phenylacyl bromides, phase transfer agent, base, solvent NIHON BAYER AGROCHEM K.K. (JP) 1994-11-01 US disclosed
EP-0534249-A2 Process for the preparation of 3-phenyl-2-propenones NIHON BAYER AGROCHEM K.K. (JP) 1993-03-31 EP disclosed