Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063380 | 0.78 | KCNA5 (0.44) | NUDT1MKNK1MKNK2SLC22A12 | |
| SCHEMBL2492073 | 0.78 | NUDT1 (0.43) | NUDT1MKNK1MKNK2CYP11B2CYP11B1 | |
| SCHEMBL2494649 | 0.78 | NUDT1 (0.41) | NUDT1MKNK1MKNK2CYP11B2CYP11B1 | |
| SCHEMBL10094229 | 0.73 | NUDT1 (0.45) | NUDT1MKNK1MKNK2SLC22A12NOTUM | |
| SCHEMBL1367450 | 0.72 | NUDT1 (0.41) | NUDT1MKNK1MKNK2CYP11B2CYP11B1 | |
| SCHEMBL2495797 | 0.71 | NUDT1 (0.48) | NUDT1MKNK1MKNK2NOTUMPIK3CD | |
| SCHEMBL4985911 | 0.70 | NUDT1 (0.40) | NUDT1MKNK1MKNK2CYP11B2CYP11B1 | |
| SCHEMBL2497924 | 0.67 | CYP11B1 (0.32) | NUDT1CYP11B2CYP11B1SLC22A12NOTUM | |
| SCHEMBL22717469 | 0.67 | MYC (0.48) | NUDT1SLC22A12NOTUM | |
| SCHEMBL2789857 | 0.67 | NUDT1 (0.55) | NUDT1MKNK1MKNK2NOTUMPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069312-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-03-12 | — | — | US | claimed |
| US-8030332-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-10-04 | — | — | US | disclosed |
| US-8030332-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-10-04 | — | — | US | disclosed |
| US-8030332-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20090069312-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-03-12 | — | — | US | disclosed |
| US-20090069312-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-03-12 | — | — | US | disclosed |
| US-20090069312-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-03-12 | — | — | US | disclosed |
| EP-1981508-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007089743-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007089743-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069312-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | NUDT1 3404/4885MKNK1 417/4885MKNK2 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.