Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205755 | 1.00 | LRRK2 (0.33) | LRRK2EML4ALKTYK2RET | |
| SCHEMBL31195396 | 0.93 | SYK (0.31) | LRRK2SYKMAPK3 | |
| SCHEMBL30205499 | 0.92 | TYK2 (0.37) | LRRK2EML4ALKTYK2SYK | |
| SCHEMBL24944982 | 0.92 | TYK2 (0.37) | LRRK2EML4ALKTYK2SYK | |
| SCHEMBL30205684 | 0.91 | SYK (0.31) | EML4ALKSYK | |
| SCHEMBL24944445 | 0.91 | SYK (0.31) | EML4ALKSYK | |
| SCHEMBL24943808 | 0.89 | EML4 (0.33) | LRRK2EML4ALKRETROS1 | |
| SCHEMBL30205492 | 0.89 | EML4 (0.33) | LRRK2EML4ALKRETROS1 | |
| SCHEMBL29173474 | 0.86 | HPGD (0.32) | TYK2 | |
| SCHEMBL30205968 | 0.86 | HPGD (0.32) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |