Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | ROS1 | P08922 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | ETV6 | P41212 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205550 | 1.00 | CAMK2D (0.40) | CAMK2DEML4ALKCDK1KDR | |
| SCHEMBL24944183 | 0.93 | SYK (0.44) | EML4ALKSYKFLT3CCNC | |
| SCHEMBL30205579 | 0.93 | SYK (0.44) | EML4ALKSYKFLT3CCNC | |
| SCHEMBL30205471 | 0.92 | IKBKE (0.38) | EML4ALKCDK1KDRSYK | |
| SCHEMBL24943812 | 0.92 | IKBKE (0.38) | EML4ALKCDK1KDRSYK | |
| SCHEMBL29173422 | 0.92 | TNIK (0.39) | CAMK2DCDK1KDRFGFR1SYK | |
| SCHEMBL24944757 | 0.90 | TBK1 (0.42) | EML4ALKCDK1KDRFGFR1 | |
| SCHEMBL24943791 | 0.88 | EML4 (0.48) | EML4ALKSYKRETROS1 | |
| SCHEMBL24943841 | 0.87 | SYK (0.38) | EML4ALKSYKRETROS1 | |
| SCHEMBL24944172 | 0.86 | TBK1 (0.39) | EML4ALKCDK1KDRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |